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THE GOOD
Approvals & Labels

AbbVie's Rinvoq (JAK inhibitor) lands EC approval for giant cell arteritis
Small molecule, giant cell arteritis - Read more

AstraZeneca and Daiichi Sankyo's ADC Datroway (targeting TROP2) lands EC approval for unresectable or metastatic hormone-positive/HER2-negative breast cancer
Antibody-drug conjugate (ADC), breast cancer - Read more

Bristol Myers Squibb's Opdivo (targeting PD-1) and Yervoy (targeting CTLA-4) combo approved by FDA for first-line metastatic colorectal cancer with MSI-H/dMMR markers
Monoclonal antibody, colorectal cancer, combo therapy - Read more

THE GOOD
Business Development

KalVista Therapeutics sells sebetralstat (PKa inhibitor) Japanese rights to Kaken Pharmaceutical for $11M upfront, with potential regulatory milestone payment and royalties
Small molecule, hereditary angioedema - Read more

Synthego licenses hfCas12Max CRISPR system to Vita Therapeutics for developing cell therapies targeting neuromuscular disorders
CRISPR, cell therapy, induced pluripotent stem cell (IPSC/iPS cell) - Read more

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✅ More Good News ✅

THE GOOD
Clinical Trials

Cartesian Therapeutics' mRNA CAR-T therapy Descartes-08 shows sustained 12-month benefit post Ph2b in generalized myasthenia gravis
Cell therapy, mRNA CAR-T, mRNA, CAR-T, myasthenia gravis - Read more

Johnson & Johnson's nipocalimab (targeting FcRn) shows sustained improvement in generalized myasthenia gravis with reduced steroid use in Ph3 trial
Monoclonal antibody, myasthenia gravis - Read more

MaaT Pharma's MaaT033 (a microbiome therapy) delivers positive safety data in Ph2b trial for patients receiving allogeneic hematopoietic stem cell transplantation
Microbiome treatment, cancer, hematopoietic stem cell, cell transplant - Read more

Annexon's tanruprubart (targeting C1q) monoclonal antibody, showed rapid recovery benefits in Ph3 trial for Guillain-Barré Syndrome
Monoclonal antibody, Guillain-Barre syndrome - Read more

Opus Genetics reports encouraging early data from teen treated with OPGx-LCA5, a gene therapy targeting LCA5 for inherited retinal disease
Gene therapy, Leber congenital amaurosis 5 (LCA5), adeno-associated virus (AAV) - Read more

THE GOOD
Company Launches

Merida Biosciences launches with $121M to develop Fc biotherapeutics targeting autoimmune and allergic diseases, starting with Graves' disease
Monoclonal antibody fragment, Graves' disease, allergic reaction, autoimmune disease - Read more

THE GOOD
Fundraises

ImmunityBio $75M equity financing, immunotherapy company developing therapies to boost immune system against cancer and infectious diseases
Small molecule, cell therapy, natural killer (NK) cells, cancer vaccine, cancer, human immunodeficiency virus (HIV), human papillomavirus (HPV) infection - Read more

4Moving Biotech receives €7.6M ($8.4M) grant to accelerate Phase 2a clinical trial of osteoarthritis drug, 4P004 (GLP-1R agonist)
GLP-1, osteoarthritis, peptide - Read more

Accure Therapeutics $1.6M grants, developing ACT-02 (targeting PREP) in Parkinson's disease treatment
Small molecule, Parkinson's disease - Read more

Stramsen Biotech $25M funding, plant-based biopharmaceutical developer preparing for IPO and drug candidates
Plant-based medicines, plant-based biotech - Read more

QurieGen €2.2M ($2.4M) funding, developing QuRIE-seq platform for enhanced drug discovery through cellular response decoding
Single cell analysis, drug discovery, drug development - Read more

Ingenix raises €9M ($9.8M) Seed, developing AI model for clinical trial simulations to accelerate pharmaceutical development
AI, clinical trial simulations, drug simulation - Read more

THE GOOD
Investments

UK investing $764M with Wellcome Trust in health data repository and fast-tracking clinical trials to boost medical research
Public-private partnership, National Health Service (NHS), clinical data, electronic health records - Read more

Novo Nordisk invests $1.09B to expand Brazilian plant, adding capacity for GLP-1 drugs and creating 600 jobs by 2028
GLP-1, injectables manufacturing, facility expansion - Read more

THE GOOD
Lawsuits

Pacira BioSciences settles patent litigation with three companies over Exparel (targeting Na_V), preventing generic versions until patents expire
Small molecule, pain, non-opioid pain, generic, patent suit - Read more

THE GOOD
Mergers & Acquisitions

Bain Capital acquires Blackstone-backed healthcare software company HealthEdge for $2.6 billion, with Blackstone exiting its controlling stake
Software, AI, health insurance, prior authorization (health insurance) - Read more

Kandu Health and Neurolutions merge, raising $30M to combine BCI technology with telehealth for stroke recovery
Brain-computer interface, telehealth, stroke - Read more

THE GOOD
Politics & Policy

Congressional commission proposes $15B over five years to boost US biotech sector, which they say risks falling behind China
Public funding, biosecurity, biotech ecosystem - Read more

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THE BAD
Clinical Trials

Rallybio discontinues RLYB212 (targeting HPA-1a) for fetal and neonatal alloimmune thrombocytopenia after Ph2 flop, shifting focus to RLYB116 (c5 inhibitor)
Monoclonal antibody, fetal and neonatal alloimmune thrombocytopenia - Read more

THE BAD
Earnings & Finances

Walgreens reports $2.85B Q2 loss with $4.2B impairment charges, continues to cut costs as privatization nears
Pharmacy, direct-to-consumer - Read more

THE BAD
Lawsuits

Novo Nordisk challenges HHS in court over Medicare price negotiation eligibility for its insulin products
US Department of Health & Human Services (HHS), Inflation Reduction Act, drug pricing - Read more

Trump administration appeals judge's block on 15% cap for NIH grant recipients' indirect cost reimbursements
National Institute of Health (NIH), federal research funding, indirect research funding - Read more

THE BAD
Layoffs

Tango Therapeutics cuts 20% of staff, reduces preclinical research
Small molecule, cancer - Read more

THE UGLY
Politics & Policy

HHS layoffs eliminated NIH's pain policy office, disrupting research affecting 17 million Americans living with chronic pain
Research center, research layoffs, public agency layoffs, pain, Research & Development, National Institute of Health (NIH) - Read more [Paywall]

Pharma CEOs warn over $100 billion in EU pharma investments could shift to the US amid President Trump's tariff threats, urging radical policy changes
Biotech ecosystem, biotech Investing, tariffs - Read more

NIH blocks researchers from China, Russia, and other "countries of concern" from accessing multiple medical and scientific databases
National Institute of Health (NIH), geopolitics, clinical data, health data - Read more

You’re all caught up on the latest Pharma & Biotech News!

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