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THE GOOD
Approvals & Labels

Vertex Pharmaceuticals' Journavx (targeting NaV1.8) lands FDA approval for acute post-surgical and injury-related pain; non-opioid pain alternative
Small molecule, pain, non-opioid pain relief - Read more

Axsome Therapeutics' Symbravo receives FDA approval for treating acute migraine in adults
Small molecule, migraine, drug delivery - Read more

THE GOOD
Business Development

Emmaus Life Sciences' Endari (L-glutamine) granted market exclusivity in Saudi Arabia for treating sickle cell disease
Small molecule, sickle cell disease, market exclusivity - Read more

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⬇️ More Good News ⬇️

THE GOOD
Clinical Trials

Tectonic Therapeutic's TX45 (targeting RXFP1) delivers positive Ph1b results for pulmonary hypertension in heart failure with preserved ejection fraction
Fusion protein, pulmonary hypertension, heart failure - Read more

Merck & Co. Winrevair (activin signaling inhibitor) Ph3 trial in pulmonary arterial hypertension delivers results good enough to warrant stopping said trail, offering med to all 172 trial participants
Fusion protein, pulmonary arterial hypertension - Read more

Shionogi and UBE showcase positive Ph2 data for oral RSV antiviral S-337395 (RNA polymerase inhibitor)
Small molecule, respiratory syncytial virus (RSV) - Read more

Ethris's touts positive Ph1 data for nasally-delivered ETH47 (encoding interferon lambda) for uncontrolled asthma
mRNA, uncontrolled asthma, nasal delivery, drug delivery - Read more

Alterity Therapeutics' ATH434 (iron chelator) delivers Ph2 data in multiple system atrophy
Small molecule, multiple system atrophy - Read more

Agenus' published new Ph1 data for botensilimab (anti-CTLA-4) and balstilimab (anti-PD-1) combo, showing promise in relapsed/refractory metastatic sarcomas and other cancers
Monoclonal antibody, sarcoma, cancer - Read more

THE GOOD
Company Incubation

EU launches hub to help biotech companies, especially startups, access support and bring innovative products to market.
Company creation, company incubation - Read more

THE GOOD
Earnings & Finances

Sanofi's RSV drug Beyfortus (targeting F protein on RSV surface) hits €1.7B in first-year sales, helping drive company's 11.3% revenue growth in 2024.
Monoclonal antibody, respiratory syncytial virus (RSV) - Read more

Lonza reports 2.1% sales decline in 2024, but company remains optimistic about future performance and market position.
CDMO - Read more

Roche's eye drug Vabysmo (targeting Ang-2, VEGF-A) achieves $4.3B in annual sales, becoming company's third-best seller while competing with Regeneron's product
Monoclonal antibody, wet age-related macular degeneration (nAMD), diabetic macular edema (DME), macular edema following retinal vein occlusion (RVO) - Read more

THE GOOD
Fundraises

Blackstone $1.6B raised of $5B+ target for new life science-focused fund
Venture capital, biotech investing, life science investing - Read more [Paywall]

Rad AI $60M Series C, healthcare AI company expanding operations and R&D in medical field
Radiology, healthcare, AI - Read more

Ypsilon Therapeutics $2.7M grant funds, developing TCRm antibodies for solid tumor treatments
T-cell receptor mimic antibody, solid tumor, cancer - Read more

Silexion Therapeutics $3.3M warrant exercise, RNAi therapy developer for KRAS-driven cancers
RNAi, siRNA, pancreatic cancer - Read more

Bicycle Health $16.5M Growth round, virtual opioid treatment provider expanding nationwide while achieving profitability
Virtual health, opioid use disorder - Read more

Immunome $150M public offering, funding ADC and radiopharmaceutical ambitions
Antibody-drug conjugate, radiopharm, cancer - Read more

GENFIT €185M ($192M) royalty financing deal with HealthCare Royalty, liver disease biotech
Small molecule, liver disease, liver failure - Read more

THE GOOD
Investments

Upperton Pharma Solutions opens £7M sterile facility in Nottingham for manufacturing liquid and powder drugs for various delivery methods
Manufacturing, sterile manufacturing, injectables - Read more

THE GOOD
Lawsuits

Regeneron notches legal win as federal appeals court upholds ban on Samsung Bioepis and Formycon's Eylea (targeting VEGF) biosimilars
Fusion protein, neovascular age-related macular degeneration (wet AMD), macular oedema secondary to retinal vein occlusion, diabetic macular oedema, biosimilar - Read more

THE GOOD
Mergers & Acquisition

Sanofi plans increased M&A activity due to strong finances, with interest in Chinese drug innovation opportunities
M&A strategy, big pharma - Read more

THE GOOD
Partnerships

Deerfield Management, University of Chicago launch $130M Hyde Park Discovery partnership to develop novel therapeutics and treatments
Drug development, translational, company creation - Read more

Kinectrics, Isotopia partner to supply Gd-160 for advancing Tb-161 radiotherapy cancer treatments
Radiopharm, cancer, supply agreement, isotope supply - Read more

Siolta Therapeutics, Cowellnex partner to develop live biotherapeutic product for preventing necrotizing enterocolitis in premature infants
Live biotherapeutics, necrotizing enterocolitis - Read more

OSE Immunotherapeutics, Scienta Lab partner to use AI platform for identifying immunotherapy biomarkers and patient response prediction
Biomarker, predictive medicine, disease modelling, inflammatory disease, AI - Read more

THE GOOD
Politics & Policy

Senator Bill Cassidy expresses concerns about confirming RFK Jr. as Health Secretary due to his anti-vaccine stance and public influence
Vaccine, anti-vax, HHS nomination - Read more

THE GOOD
Public Health

Survey shows 74% of US voters support wide vaccine availability, contrasting with RFK Jr.'s vaccine skepticism ahead of Senate hearing
Vaccine, anti-vax - Read more

THE GOOD
Research

Scientists discover brain circuit that could lead to anxiety treatment with fewer side effects through new mapping techniques
Brain mapping, anxiety - Read more

AstraZeneca antibody shows promise in protecting against severe bird flu in macaques
Antibody, bird flu - Read more

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THE BAD
Clinical Trials

Takeda discontinues soticlestat (CH24H inhibitor) development after Ph3 trials endpoints miss in reducing seizures for Dravet syndrome and Lennox-Gastaut syndrome epilepsy patients
Small molecule, Dravet syndrome, Lennox-Gastaut syndrome epilepsy - Read more

Inhibikase Therapeutics halts risvodetinib (c-Abl kinase inhibitor) Ph2 trial in Parkinson's disease due to efficacy failure
Small molecule, Parkinson’s disease - Read more

Roche discontinues Ph1 runimotamab (targeting HER2xCD3) for breast cancer and cuts Xencor-partnered efbalropendekin alfa (IL-15 modulator) candidate
Bispecific antibody, recombinant fusion protein, breast cancer, multiple myeloma, cancer - Read more

THE BAD
Layoffs

Ironwood Pharmaceuticals cuts workforce after projecting lower-than-expected 2025 revenue, causing stock price drop
Peptide, short bowel syndrome with intestinal insufficiency (SBS‐II), intestinal failure (SBS‐IF) - Read more

Switch Therapeutics layoffs as confirmed to Endpoints
RNAi, siRNA, Alzheimer’s disease, progressive supranuclear palsy - Read more [Paywall]

ReCode Therapeutics layoffs as confirmed to Endpoints
mRNA, lipid nanoparticle, drug delivery, primary ciliary dyskinesia (PCD), cystic fibrosis (CF) - Read more [Paywall]

THE BAD
Strategic Plans

Rentschler Biopharma exits cell and gene therapy market, closes UK site to focus on biologics amid strategic realignment
CDMO, cell & gene therapy manufacturing - Read more

THE UGLY
Public Health

Uganda reports Ebola death of nurse in Kampala after he sought care at multiple facilities before diagnosis (I hope the WHO is well funded…)
Ebola, infectious disease - Read more [Paywall]

You’re all caught up on the latest Pharma & Biotech News!

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