- TLDR Biotech
- Posts
- Biotech & Pharma Updates | November 21 - 24, 2024
Biotech & Pharma Updates | November 21 - 24, 2024
BridgeBio's Attruby lands FDA approval, Roche's Vabysmo touts potentially lucrative (in Asia) Ph3b/4 data in polypoidal choroidal vasculopathy, Nabla Bio's coming for the AI-designed protein crown, ALS hopeful Seelos Therapeutics files for bankruptcy + 21 more stories

BridgeBio’s Attruby (transthyretin stabilizer) nabs FDA approval in transthyretin amyloid cardiomyopathy. | Gif: nobodiestv on Giphy
All the top Biotech & Pharma news in one daily newsletter.
Want to understand how these updates are formatted? Check-out the FAQ.
Have any feedback? I’d love to hear you from - connect with me on LinkedIn. 📣
Looking to reach an audience of 1400+ biotech and pharma professionals? Let’s chat. 👍
⬇️ The Good News ⬇️
THE GOOD
Approvals & Labels
BridgeBio’s Attruby (transthyretin stabilizer) nabs FDA approval in transthyretin amyloid cardiomyopathy
Small molecule, transthyretin amyloid cardiomyopathy - Read more
Merck & Co.’s Welireg (HIF inhibitor) nabs China NMPA approval for von Hippel-Lindau (VHL) disease with certain solid tumors
Small molecule, von Hippel-Lindau disease, cancer - Read more
Zenyaku Kogyo, Chugai Pharmaceutical land Japan MHLW label expansion for Rituxan (anti-CD20) in treating chronic idiopathic thrombocytopenic purpura
Monoclonal antibody, chronic idiopathic thrombocytopenic purpura - Read more
GSK’s Arexvy scores expanded RSV vaccination label by Japan’s MHLW to adults aged 50-59 (original approval for adults over aged 60)
Vaccine, respiratory syncytial virus - Read more
StemCyte’s Regenecyte BLA approved by FDA, in combo with appropriate prep regimen for hematopoietic and immunologic reconstitution in certain patients
Cell therapy, donor hematopoietic progenitor cell transplantation, allogeneic hematopoietic stem cell - Read more
THE GOOD
Business Development
Vilya in-licenses peptide structure prediction framework from University of Washington
Peptide, drug discovery, machine learning - Read more
Otsuka Pharmaceutical lands exclusive global licensing rights to Ionis Pharmaceuticals’ ulefnersen (targeting RNA-binding protein fused in sarcoma/translocated in liposarcoma), potential ALS treatment
Antisense oligonucleotide, amyotrophic lateral sclerosis (ALS) - Read more
PRESENTED BY YOU?
Get the attention of 1400+ Biotech & Pharma Professionals 🤩

Gif: oscars on Giphy
Do you offer a biotech/pharma-focused product or service?
Or looking to get investor/analyst interest on your budding start-up?
Considering sponsoring TLDR Biotech to get in-front of an engaged audience of biotech & pharma-focused professionals.
Just reply to this email* or message me on LinkedIn to learn more.
*If you’re reading this on the web version, email [email protected]
⬇️ More Good News ⬇️
THE GOOD
Clinical Trials
Gan & Lee Pharmaceuticals touts positive Ph2b data for GZR18 (GLP-1 receptor agonist)
GLP-1, obesity - Read more [Press release in Chinese]
Lumos Pharma showcases new Ph2 data analyses for LUM-201 (growth hormone secretagogue) in pediatric growth hormone deficiency
Small molecule, pediatric growth hormone deficiency - Read more
Roche’s Vabysmo (VEGF, Ang-2 targeting) builds expanded label case with Ph3b/4 data in polypoidal choroidal vasculopathy
Bispecific antibody, polypoidal choroidal vasculopathy, neovascular AMD - Read more
THE GOOD
Fundraises
OncoVerity undisclosed Series A extension, proceeds to fund Ph2 for cusatuzumab (anti-CD70) in acute myeloid leukemia
Monoclonal antibody, acute myeloid leukemia, cancer, bioinformatics - Read more
THE GOOD
Patient Access
Baxter releases first batch of IV solutions post-hurricane from North Cove, NC facility
IV solutions, manufacturing, supply chain - Read more
Sanofi makes suggestions to US’s 340B system with “Innovate Credit System”
340B drug pricing program, drug pricing - Read more
THE GOOD
Politics & Policy
US’s PREVAIL Act, related to drug patent challenges, narrowly moved forward to Senate floor vote
Drug patent, drug pricing - Read more
THE GOOD
Product Development
Nabla Bio posts technical paper on AI-enabled protein design tech
Drug design, biologics, AI, de novo - Read more
Illumina previews updated tumor profiling research assay
Genomic testing, cancer, research & development - Read more
THE GOOD
Research
Washington University researcher publish immune checkpoint inhibitor-releasing probiotic yeast as potential gut tumor drug delivery method
Drug delivery, solid tumor, cancer - Read more
ENJOYING THESE NEWSLETTERS?
Support TLDR Biotech🧬🦠🔬
I’m offering this newsletter for free so it can get out to as many people as possible.
If you’re getting value out of these daily compilations, please consider a paid subscription (only $5/month) to support my continued work on this project.*
*Best of all, it’s a work-related news source that you can likely expense. 😉
⬇️ The Bad News ⬇️
THE BAD
Company Shutdown
Seelos Therapeutics files for bankruptcy
Small molecule, amyotrophic lateral sclerosis, post-traumatic stress disorder - Read more
THE BAD
Lawsuits
Johnson & Johnson’s talc saga continues as UK lawsuits may be ramping up
Talc, cancer - Read more
THE BAD
Layoffs
Lexicon Therapeutics shutters commercial division and 60% of staff due to Zynquista approval package “deficiencies” per FDA
Small molecule, type 1 diabetes, insulin therapy adjunct - Read more
THE BAD
Mergers & Acquisitions
Halozyme Therapeutics withdraws Evotec acquisition proposal after getting the silent treatment
Drug delivery tech platform, drug discovery - Read more
THE BAD
Regulatory
FDA still undecided on tirzepatide “shortage”, much to continued delight of compounding pharmacies
GLP-1, obesity, drug compounding - Read more
THE BAD
Public Health
Florida’s surgeon general goes against the research on fluoride
Water fluoridation, oral health - Read more [Paywall]
THE BAD
Strategic Plans
AstraZeneca drops AZD4041 (orexin receptor type 1 agonist) Ph2 trial
Small molecule, opioid use disorder - Read more
⬇️ The Ugly News ⬇️
THE UGLY
Clinical Trials
Neurogene reports death in high-dose cohort of Rett syndrome gene therapy NGN-401, likely due to AAV over-exposure
Gene therapy, Rett syndrome, AAV - Read more
You’re all caught up on the latest Pharma & Biotech News!

Hope you have a wonderful Monday! | Gif: yevbel on Giphy
TLDR Biotech wants to hear from you! 📣
Have comments/questions/complaints about this newsletter?
Send me an email - I want your brutally honest feedback. 📝
Last thing - if you find the content useful and think a colleague would too, please share TLDR Biotech with them! ♻️
Disclaimer: Content, news, research, tools, and mention of stock or tradeable securities are for educational and illustrative purposes only and do not imply a recommendation or solicitation to buy or sell a particular security or to engage in any particular investment strategy. Read the full terms & conditions here