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THE GOOD
Approvals & Labels

Caris Life Sciences’ multicancer companion diagnostic nabs FDA approval
Cancer therapy efficacy assement, companion diagnostic - Read more 

THE GOOD
Business Development

Advent International considers selling Zentiva for €5B ($5.4B)
Generics, company sale - Read more [Paywall]

Evotec sells Halle-based CDMO site to Monacum Partners
CDMO, manufacturing, site sale - Read more

THE GOOD
Clinical Trials

Ascletis Pharma touts “promising” Ph1 results for muscle-preserving weight-loss hopeful ASC47
Small molecule, obesity, muscle-preserving - Read more [Original press release in Chinese]

ImPact Biotech’s updated Ph3 interim data for small molecule + photodynamic therapy combo Padeliporfin VTP in urothelial cancer
Small molecule, urothelial cancer, photodynamic therapy - Read more

Denali Therapeutics’ touts “robust” Ph1/2 preliminary results for DNL126 enzyme replacement therapy for Sanfilippo syndrome type A
Enzyme replacement therapy, Sanfilippo syndrome type A - Read more

THE GOOD
Company Launches

Oblenio Bio launches from Aditum Bio and Leads BioLabs initiative, focusing on progressing LBL-051 tri-specific T-cell engager antibody for autoimmune disorders
Tri-specific T-cell engager antibody, autoimmune disorder - Read more

Corundum Convergence Institute non-profit launches with aim to support research in neurobiology, systems biology, and AI
Research & development, neurobiology, systems biology, AI - Read more

THE GOOD
Earnings & Finances

Gilead posts strong Q3, driven by human HIV business, and raises full year guidance
Antiretroviral, human immunodeficiency virus - Read more

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THE GOOD
Fundraises

Geron sign up to $375M in synthetic royalty, debt financing deal with Royalty Pharma, Pharmakon Advisors
Oligonucleotide, myelodysplastic syndromes, transfusion dependent anemia - Read more

JP Morgan is looking to raise a new life science fund focused on late-stage companies
Biotech investing, banking - Read more [Paywall]

Dovetail Genomics $2M SBIR Grant for developing genomic testing for oncology samples
Genomic testing, cancer, proximity ligation technologies - Read more

Reneural Technologies £475k ($614k) Pre-seed raise, stroke recovery and support
Medical device, stroke, neurorehabilitation - Read more

THE GOOD
Investments

Pfizer planning to invest over $1B in China over the next 5 years
Expansion - Read more [Paywall]

THE GOOD
Mergers & Acquisitions

Avid Bioservices goes private via GHO Capital Partners and Ampersand Capital Partners acquisition, $1.1B all-cash transaction
CDMO, manufacturing - Read more

NeuroReality acquired by XRHealth, therapeutic VR and XR tech
Virtual healthcare, virtual reality, extended reality - Read more 

THE GOOD
Partnerships

Juntendo University, Metagen Therapeutics joint research collab on Fecal Microbiota Transplantation on Parkinson’s disease
Fecal microbiota transplantation, Parkinson’s disease, research & development - Read more

Forus Therapeutics, PharmaEssentia licensing agreement to register, commercialize Besremi in Canada
Interferon, polycythemia vera - Read more

THE GOOD
Research

Team from Stanford University, Boundless Bio shrink gastric tumors in mice with small molecule BBI-2779, targeting extrachromosomal DNA
Small molecule, gastric cancer, extrachromosomal DNA - Read more

Recent publications detail how DNA circles (ecDNA) are involved in many human cancers, both in its development and treatment resistance
DNA circles, cancer - Read more

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THE BAD
Clinical Trials

Rapport Therapeutics’ diabetic peripheral neuropathic pain candidate RAP-219 hit with FDA clinical hold, delaying Ph2a trial start
Small molecule, diabetic peripheral neuropathic pain - Read more

ADC Therapeutics’ solid tumor hopeful ADCT-601 falls flat in Ph1b, asset development axed
Antibody-drug conjugate, solid tumor, cancer - Read more

THE BAD
Earnings & Finances

Moderna’s better-than-expected COVID-19 sales in Q3 overshadowed by disappointing RSV jab earnings
Vaccine, respiratory syncytial virus, COVID-19 - Read more

“This is the new Teva [Pharmaceuticals]” doesn’t convince investors despite beating Q3 predictions
Generic, biosimilar - Read more

Gilead’s CAR-T sales stay flat, while ADC division faces challenges as Trodelvy takes $1.75B impairment charge
Cell therapy, liquid tumor, antibody-drug conjugate, lung cancer - Read more

THE BAD
Layoffs

Viracta Therapeutics “resource reprioritization” claims 42% of existing staff
Small molecule, Epstein–Barr virus–positive peripheral T-cell lymphoma - Read more

Aurinia Pharmaceuticals cuts 45% of workforce
Small molecule, lupus - Read more

Trevena’s “strategic review” shrinks team to four, bye-bye to CEO and other C-suite execs
Small molecule, acute pain, opioid - Read more

THE BAD
Patient Access

Zentiva blames EU for future drug shortages related to costs stemming from the Urban Wastewater Treatment Directive
Pollution, extended producer responsibility, micropollutants - Read more

THE BAD
Strategic Plans

Celldex Therapeutics drops CDX-585 bispecific after Ph1, prioritizes inflammatory space advancement
Bispecific antibody, solid tumor, cancer - Read more

Genmab cuts triad of cancer-focused antibodies; GEN1047, GEN3017, GEN1056
Bispecific antibody, antibody, lymphoma, solid tumor - Read more

Sarepta Therapeutics scraps development of DMD oligo SRP-5051 as Elevidys sales continue to rise
Antisense oligonucleotide, Duchenne muscular dystrophy - Read more

THE UGLY
Criminal Acts

AstraZeneca China saga escalates, as senior executive now in custody
Insurance fraud, cancer, oncology - Read more [Paywall]

THE UGLY
Research

A staggering 72% of biomedical researchers say field is facing a reproducibility crisis
Research reproducibility - Read more

THE UGLY
Withdrawals & Recalls

FDA moves to remove phenylephrine-containing nasal decongestants, as it turns out they probably don’t work
Small molecule, nasal decongestant - Read more

You’re all caught up on the latest Pharma & Biotech News!

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