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  • Biotech & Pharma Updates | October 29 - 30, 2024

Biotech & Pharma Updates | October 29 - 30, 2024

Biogen’s up to $1.45B molecular glue degrader deal with Neomorph, Roche posts promising Ph1b/2a amyloid plaque clearing bispecific data, Archon Biosciences launches with $20M seed and dreams of “antibody cages”, the sky is the limit for AbbVie’s Skyrizi after Q3 earnings, Axonis $115M Series A to go after pain & epilepsy, Blue Earth Therapeutics $76.5M Series A for next-gen radioligands, Servier & Aitia expand digital twin-driven glioma drug discovery partnership, Eli Lilly’s GLP-1 earnings fly too close to the sun, Spero Therapeutics cuts 39% of workforce after antibiotic disappoint, Eli Lilly & GSK both cut assets from multi-billion dollar acquisition, AstraZeneca’s China operations president under Chinese authority investigation

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⬇️ The Good News ⬇️

THE GOOD
Business Development

Biogen buys access to Neomorph’s molecular glue degrader platform for up to $1.45B
Small molecule, Alzheimer’s, autoimmune, drug discovery, molecular glue degraders - Read more 

THE GOOD
Clinical Trials

Roche posts promising interim Ph1b/2a data for trontinemab in clearing amyloid plaque, despite one patient death
Bispecific antibody, Alzheimer’s disease - Read more

Lexeo Therapeutics posts positive interim Ph1 data for Alzheimer’s disease gene therapy hopeful LX1001
Gene therapy, Alzheimer’s disease, AAV - Read more

CalciMedica touts positive Ph2b data for small molecule Auxora in acute pancreatitis
Small molecule, acute pancreatitis - Read more

Soal Therapeutics’ positive topline Ph2 results for SL-1002 in limb spasticity
Small molecule, limb spasticity - Read more

Amplia Therapeutics posts “excit[ing]” interim Ph2a data for narmafotinib in pancreatic cancer
Small molecule, pancreatic cancer - Read more

Cognition Therapeutics posts pre-specific analysis of Ph2 data for CT1812 in Alzheimer’s disease
Small molecule, Alzheimer’s disease - Read more

Sobi touts pooled Ph3 analysis data for mAb emapalumab in two rare autoinflammatory conditions
Monoclonal antibody, systemic juvenile idiopathic arthritis, adult-onset still's disease - Read more

reMYND showcases positive Ph2a data for REM0046127 in Alzheimer’s disease
Small molecule, Alzheimer’s disease - Read more

THE GOOD
Company Launches

Archon Biosciences launches with $20M seed, drug discovery in new class of therapeutics dubbed “antibody cages”
Antibody cages, drug discovery, AI - Read more

THE GOOD
Earnings & Finances

AbbVie lifts full year profit guidance as Skyrizi sales soar to new heights
Monoclonal antibody, plaque psoriasis, psoriatic arthritis, Crohn's disease - Read more

Incyte’s pins hopes on three upcoming launches to solve their upcoming patent cliff woes
Monoclonal antibody, cancer - Read more

Biogen raises guidance on after strong performance, even from controversial Alzheimer’s med Leqembi
Monoclonal antibody, Alzheimer’s disease - Read more

BioMarin’s earnings shoot past estimates, driven by rare genetic disease therapy growth
Small molecule, achondroplasia, gene therapy, hemophilia A - Read more

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⬇️ More Good News ⬇️

THE GOOD
Fundraises

Axonis $115M Series A, small molecules for neurological disorders
Small molecule, pain, epilepsy - Read more

Blue Earth Therapeutics $76.5M Series A for next-gen radioligand therapies
Radiopharm, prostrate cancer, radioligand - Read more

TXN Systems SEK25M ($2.3M) Series A, develop antibiotics for multi-drug resistant UTIs
Small molecule, urinary tract infection, multi-drug resistant infection - Read more

Leal Therapeutics $45M financing, ALS and schizophrenia therapies
Antisense oligonucleotide, amyotrophic lateral sclerosis, small molecule, schizophrenia - Read more

SynOx Therapeutics adds $17M to top-up their Series B for mAb treating tenosynovial giant cell tumours
Monoclonal antibody, tenosynovial giant cell tumour - Read more

Vaxinano €6M ($6.5M) raise, nasal vaccines
Vaccines, infectious disease, nasal vaccines - Read more

Vara $8.9M raise for AI-powered breast cancer detection
Breast cancer detection, AI - Read more

Experic undisclosed growth investment
CDMO, manufacturing - Read more

THE GOOD
Partnerships

Servier, Aitia expand partnership, leveraging AI, digital twins for glioma drug discovery
Drug discovery, glioma, cancer, AI, digital twin - Read more

SandboxAQ, The Michael J. Fox Foundation partner on developing novel Parkinson’s disease therapies
Drug development, Parkinson’s disease - Read more

Biond Biologics, Merck KGaA clinical trial collab for BND-35 + cetuximab in solid tumor-targeting Ph1
Monoclonal antibody, solid tumor, cancer - Read more

Insilico Medicine, Sanofi announce AI-facilitated lead identification as part of drug discovery partnership
Drug discovery, cancer, AI - Read more

Catalent, IsomAb strategic collaboration, cell line development
Antibody, type 2 diabetes, peripheral artery disease, process development - Read more

THE GOOD
Patient Access

Novo Nordisk looks to have quelled Ozempic, Wegovy shortages, though patients may still experience “variability” in access
GLP-1, obesity, type 2 diabetes - Read more

THE GOOD
Research

3D tumor renderings provide fresh insights into tumor growth
3D rendering, tumor growth, cancer - Read more

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⬇️ The Bad News ⬇️

THE BAD
Earnings & Finances

Eli Lilly’s obesity money-makers disappoint investors as quarter-over-quarter sales growth didn’t happen
GLP-1, obesity, type diabetes - Read more

GSK earnings a dud as RSV, shingles shot sales sputter
Vaccine, respiratory syncytial virus, shingles - Read more

THE BAD
Layoffs

Spero Therapeutics cuts 39% of staff after antibiotic disappointment
Small molecule, nontuberculous mycobacterial pulmonary disease, antibiotic - Read more

Walgreens continues cost-cutting tirade with 256 slashed support centre roles
Pharmacy, healthcare, retail - Read more

THE BAD
Strategic Plans

Eli Lilly’s $2.4B Dice Therapeutics gamble not looking so hot after lead program (DC-806) development cut
Small molecule, psoriasis - Read more

GSK also cuts development of an asset from a billion dollar+ acquisition, pneumococcal vaccine from $2.1B Affinivax takeover
Vaccine, pneumococcal disease - Read more

⬇️ The Ugly News ⬇️

THE UGLY
Criminal Acts

AstraZeneca’s China operations president under investigation by Chinese authorities; reasons for investigation undisclosed - Read more

You’re all caught up on the latest Pharma & Biotech News!

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